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KMID : 0614620040430010029
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Korean Journal of Gastroenterology
2004 Volume.43 No. 1 p.29 ~ p.34
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Clinical Features and Prognostic Factors in Primary Adenocarcinoma of the Appendix
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박인자/Park IJ
유창식/김희철/김진천/Yu CS/Kim HC/Kim JC
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Abstract
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Background/Aims: Primary appendiceal adenocarcinoma is a rare neoplasm that constitutes less than 0.5% of all gastrointestinal neoplasm. The aim of this study was to figure out its clinicopathologic characteristics that are not well understood.
Methods: We reviewed the medical records of nineteen patients (9 males and 10 females) with histologically proven appendiceal adenocarcinoma. They had been treated at Asan Medical Center between June 1989 and December 2002. Their median follow-up duration was 72.5 months.
Results: Their median age was 56.5 (range, 33~80) years. Thirteen patients had mucinous variants and the other five had adenocarcinoma. Seven patients (36.8%) were diagnosed as acute appendicitis. In fact, none of the patients was diagnosed correctly before surgery. The operative procedure, included right hemicolectomy in 9 patients, appendectomy alone in 2 patients, and debulking of their tumors or a biopsy in 8 patients. The 5-year survival rate was 20.5%. The patients with mucinous type had better prognosis than those with the non-mucinous type (p＜0.01). In the patients with mucinous type, the survival rate after debulking operation was similar to that after right hemicolectomy.
Conclusions: The most important prognostic factor of primary appendiceal adenocarcinoma was histology. The outcome of debulking operation is being watched compared with that of right hemicolectomy in mucinous variant.
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